合肥科生景肽生物科技有限公司
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——团队建设

科生景肽汇聚全球顶尖专业技术人才,核心团队来自于佛罗里达州立大学、Vanderbilt大学(Nashville)、哥伦比亚大学、美国斯克利普斯研究所、中国科技大学、清华大学、北京大学、上海交通大学等国内外知名大学和研究机构,拥有多项国内唯一、国际领先的困难多肽合成技术;联合中国科技大学生命学院、化学学院、先进技术研究院、中科院药物所及苏州药物创新研究院等机构,以定向培养、合作培养、实习基地、学术论坛等模式创建联合人才培养基地,为多肽药物创新提供产业化发展需要的高端技术及管理人才。



——论文发表

Liang,  J., Zhang, L., Tan, X. L., Qi, Y. K., Feng, S., Deng, H., Yan, Y., Zheng, J.  S., Liu, L. and Tian, C. L. (2017)."Chemical  Synthesis of Diubiquitin‐Based Photoaffinity Probes for Selectively Profiling  Ubiquitin‐Binding Proteins"AngewChem Int Ed Engl56(10):  2744‐2748.

Li,  J. B., Tang, S., Zheng, J. S., Tian, C. L. and Liu, L. (2017)."Removable Backbone Modification Method for the Chemical  Synthesis of Membrane Proteins"Acc Chem Res 50(5):  1143‐1153.


Li,  J., He, Q., Liu, Y., Liu, S., Tang, S., Li, C., Sun, D., Li, X., Zhou, M., Zhu,  P., Bi, G., Zhou, Z., Zheng, J. S. and Tian, C. (2017)."Chemical Synthesis of K34‐Ubiquitylated H2B for  Nucleosome Reconstitution and Single‐Particle Cryo‐Electron Microscopy  Structural Analysis"Chembiochem 18(2): 176‐180.

Zuo,  C., Tang, S., Si, Y. Y., Wang, Z. A., Tian, C. L. and Zheng, J. S. (2016)."Efficient synthesis of  longer Abeta peptides via removable backbone modification"Org  Biomol Chem 14(22): 5012‐5018.

Zheng,  Q. Y., Wang, T., Pan, M., Li, Y. M. and Tian, C. L. (2016)."Selectivity and Mechanism of Polyubiquitin Chain  Hydrolases"Progress in Biochemistry and Biophysics 43(9): 864‐879.


Zheng,  J. S., He, Y., Zuo, C., Cai, X. Y., Tang, S., Wang, Z. A., Zhang, L. H., Tian,  C. L. and Liu, L. (2016)."Robust  Chemical Synthesis of Membrane Proteins through a General Method of Removable  Backbone Modification"JAm Chem Soc138(10):  3553‐3561.

Yu,  M., Liu, S. L., Sun, P. B., Pan, H., Tian, C. L. and Zhang, L. H. (2016)."Peptide toxins and  small‐molecule blockers of BK channels"Acta Pharmacol Sin 37(1): 56‐66.


Wang,  Z. P. A., Tian, C. L. N. and Zheng, J. S. (2016)."The  Structural Designs and Property Analysis of Polyamide Based Structures as  Peptide Secondary Structure Mimics"Progress in Chemistry 28(9):  1328‐1340.

Wang,  Z. P. A., Ding, X. Z. Z., Tian, C. L. and Zheng, J. S. (2016)."Protein/peptide secondary structural mimics: design,  characterization, and modulation of protein‐protein interactions"Rsc  Advances 6(66): 61599‐61609.


Huang,  Y. C., Chen, C. C., Gao, S., Wang, Y. H., Xiao, H., Wang, F., Tian, C. L. and  Li, Y. M. (2016)."Synthesis of  l‐ and d‐Ubiquitin by One‐Pot Ligation and Metal‐Free Desulfurization"Chemistry 22(22): 7623‐7628.

Qi,  Y. K., Chang, H. N., Pan, K. M., Tian, C. L. and Zheng, J. S. (2015)."Total chemical synthesis of  the site‐selective azide‐labeled [I66A]HIV‐1 protease"Chem Commun (Camb) 51(78): 14632‐14635.


Guo,  Y., Sun, D. M., Wang, F. L., He, Y., Liu, L. and Tian, C. L. (2015)."Diaminodiacid Bridges to  Improve Folding and Tune the Bioactivity of Disulfide‐Rich Peptides"Angew  Chem Int Ed Engl 54(48): 14276‐14281.

Zheng,  J. S., Yu, M., Qi, Y. K., Tang, S., Shen, F., Wang, Z. P., Xiao, L., Zhang, L.,  Tian, C. L. and Liu, L. (2014)."Expedient  total synthesis of small to medium‐sized membrane proteins via Fmoc  chemistry"J Am ChemSoc136(9): 3695‐3704.

Pan,  M., He, Y., Wen, M., Wu, F., Sun, D., Li, S., Zhang, L., Li, Y. and Tian, C. (2014)."One‐pot hydrazide‐based  native chemical ligation for efficient chemical synthesis and structure  determination of toxin Mambalgin‐1"Chem Commun (Camb)50(44): 5837‐5839.

Chen,  Y. Q., Chen, C. C., He, Y., Yu, M., Xu, L., Tian, C., Guo, Q., Shi, J., Zhang,  M. and Li, Y. (2014)."Efficient  synthesis of trpsin inhibitor SFTI‐1 via intramolecular ligation of peptide  hydrazide"Tetrahedron Letters 55(17): 2883‐2886.


Chen,  C., Huang, Y., Xu, L., Zheng, Y., Xu, H., Guo, Q., Tian, C., Li, Y. and Shi, J.  (2014)."Thiol‐assisted one‐pot  synthesis of peptide/protein C‐terminal thioacids from peptide/protein  hydrazides at neutral conditions"OrgBiomol Chem12(46):  9413‐9418.

Liang,  J., Fang, G., Huang, X., Mei, Z., Li, J., Tian, C. and Liu, L. (2013)."Chemical synthesis of  Ub‐AMC via ligation of peptide hydrazides"Science China Chemistry 56(9): 1301‐1306.


Cui,  H. K., Guo, Y., He, Y., Wang, F. L., Chang, H. N., Wang, Y. J., Wu, F. M.,  Tian, C. L. and Liu, L. (2013)."Diaminodiacid‐based  solid‐phase synthesis of peptide disulfide bond mimics"Angew  Chem Int Ed Engl 52(36): 9558‐9562.