——团队建设
科生景肽汇聚多名行业内顶尖专业技术人才,创业团队大都来自中科大、清华大学。拥有多项国内唯一、国际领先的困难多肽合成技术。构建联合人才培养基地。拟联合中科大生命学院、化学学院,中科大先研院、科生景肽等单位,以定向培养、合作培养、实习基地、学术论坛等模式构建“多肽中心·科生景肽联合人才培养基地”,提供科生景肽产业化发展需要的技术及管理人才。
——论文发表
Liang, J., Zhang, L., Tan, X. L., Qi, Y. K., Feng, S., Deng, H., Yan, Y., Zheng, J. S., Liu, L. and Tian, C. L. (2017)."Chemical Synthesis of Diubiquitin‐Based Photoaffinity Probes for Selectively Profiling Ubiquitin‐Binding Proteins"AngewChem Int Ed Engl56(10): 2744‐2748.
Li, J. B., Tang, S., Zheng, J. S., Tian, C. L. and Liu, L. (2017)."Removable Backbone Modification Method for the Chemical Synthesis of Membrane Proteins"Acc Chem Res 50(5): 1143‐1153.
Li, J., He, Q., Liu, Y., Liu, S., Tang, S., Li, C., Sun, D., Li, X., Zhou, M., Zhu, P., Bi, G., Zhou, Z., Zheng, J. S. and Tian, C. (2017)."Chemical Synthesis of K34‐Ubiquitylated H2B for Nucleosome Reconstitution and Single‐Particle Cryo‐Electron Microscopy Structural Analysis"Chembiochem 18(2): 176‐180.
Zuo, C., Tang, S., Si, Y. Y., Wang, Z. A., Tian, C. L. and Zheng, J. S. (2016)."Efficient synthesis of longer Abeta peptides via removable backbone modification"Org Biomol Chem 14(22): 5012‐5018.
Zheng, Q. Y., Wang, T., Pan, M., Li, Y. M. and Tian, C. L. (2016)."Selectivity and Mechanism of Polyubiquitin Chain Hydrolases"Progress in Biochemistry and Biophysics 43(9): 864‐879.
Zheng, J. S., He, Y., Zuo, C., Cai, X. Y., Tang, S., Wang, Z. A., Zhang, L. H., Tian, C. L. and Liu, L. (2016)."Robust Chemical Synthesis of Membrane Proteins through a General Method of Removable Backbone Modification"JAm Chem Soc138(10): 3553‐3561.
Yu, M., Liu, S. L., Sun, P. B., Pan, H., Tian, C. L. and Zhang, L. H. (2016)."Peptide toxins and small‐molecule blockers of BK channels"Acta Pharmacol Sin 37(1): 56‐66.
Wang, Z. P. A., Tian, C. L. N. and Zheng, J. S. (2016)."The Structural Designs and Property Analysis of Polyamide Based Structures as Peptide Secondary Structure Mimics"Progress in Chemistry 28(9): 1328‐1340.
Wang, Z. P. A., Ding, X. Z. Z., Tian, C. L. and Zheng, J. S. (2016)."Protein/peptide secondary structural mimics: design, characterization, and modulation of protein‐protein interactions"Rsc Advances 6(66): 61599‐61609.
Huang, Y. C., Chen, C. C., Gao, S., Wang, Y. H., Xiao, H., Wang, F., Tian, C. L. and Li, Y. M. (2016)."Synthesis of l‐ and d‐Ubiquitin by One‐Pot Ligation and Metal‐Free Desulfurization"Chemistry 22(22): 7623‐7628.
Qi, Y. K., Chang, H. N., Pan, K. M., Tian, C. L. and Zheng, J. S. (2015)."Total chemical synthesis of the site‐selective azide‐labeled [I66A]HIV‐1 protease"Chem Commun (Camb) 51(78): 14632‐14635.
Guo, Y., Sun, D. M., Wang, F. L., He, Y., Liu, L. and Tian, C. L. (2015)."Diaminodiacid Bridges to Improve Folding and Tune the Bioactivity of Disulfide‐Rich Peptides"Angew Chem Int Ed Engl 54(48): 14276‐14281.
Zheng, J. S., Yu, M., Qi, Y. K., Tang, S., Shen, F., Wang, Z. P., Xiao, L., Zhang, L., Tian, C. L. and Liu, L. (2014)."Expedient total synthesis of small to medium‐sized membrane proteins via Fmoc chemistry"J Am ChemSoc136(9): 3695‐3704.
Pan, M., He, Y., Wen, M., Wu, F., Sun, D., Li, S., Zhang, L., Li, Y. and Tian, C. (2014)."One‐pot hydrazide‐based native chemical ligation for efficient chemical synthesis and structure determination of toxin Mambalgin‐1"Chem Commun (Camb)50(44): 5837‐5839.
Chen, Y. Q., Chen, C. C., He, Y., Yu, M., Xu, L., Tian, C., Guo, Q., Shi, J., Zhang, M. and Li, Y. (2014)."Efficient synthesis of trpsin inhibitor SFTI‐1 via intramolecular ligation of peptide hydrazide"Tetrahedron Letters 55(17): 2883‐2886.
Chen, C., Huang, Y., Xu, L., Zheng, Y., Xu, H., Guo, Q., Tian, C., Li, Y. and Shi, J. (2014)."Thiol‐assisted one‐pot synthesis of peptide/protein C‐terminal thioacids from peptide/protein hydrazides at neutral conditions"OrgBiomol Chem12(46): 9413‐9418.
Liang, J., Fang, G., Huang, X., Mei, Z., Li, J., Tian, C. and Liu, L. (2013)."Chemical synthesis of Ub‐AMC via ligation of peptide hydrazides"Science China Chemistry 56(9): 1301‐1306.
Cui, H. K., Guo, Y., He, Y., Wang, F. L., Chang, H. N., Wang, Y. J., Wu, F. M., Tian, C. L. and Liu, L. (2013)."Diaminodiacid‐based solid‐phase synthesis of peptide disulfide bond mimics"Angew Chem Int Ed Engl 52(36): 9558‐9562.